First One Step Regioselective Acylation

The Friedel-Crafts acylation, an electrophilic aromatic substitution with electronic-controlled regioselectivity, is a commonly used method to synthesize aryl ketones. Although regioselective arene acylation using other approaches is possible, it usually requires multiple steps and precious-metal catalysts. Christopher J. Douglas and colleagues, University of Minnesota—Twin Cities, Minneapolis, USA, have developed […]

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